The Dementia Laboratory in the Department of Pathology and Laboratory Medicine at Indiana University is seeking an outstanding candidate for a postdoctoral position. The selected individual will participate in research focused on the molecular mechanisms of neurodegeneration in diseases caused by TDP-43 misfolding. The lab will also continue exploring TDP-43 in its hybrid form as associated with annexin A11. These research projects are funded by the NINDS and will be carried out under the direction of Drs. Kathy L. Newell and Laura Cracco. The studies will be carried out using methodologies of proteomics and genetics. Protein extraction from the brain tissue of individuals with frontotemporal dementias, TDP-43 characterization by biochemical methods and transmission electron microscopy will take place in parallel with neuropathological and structural studies.

The Dementia Laboratory has active collaborations with national and international laboratories including the MRC Laboratory of Molecular Biology (Cambridge, UK) and ICGEB (Trieste, Italy). The successful candidate will have the opportunity to contribute to cutting-edge research, with the potential for publication in high impact factor journals.

Indiana University School of Medicine - IUSM is committed to being a welcoming campus community and we seek candidates whose research, teaching, and community engagement efforts contribute to robust learning and working environments for all students, staff, and faculty. We invite individuals who will join us in our mission to improve health equity and well-being for all throughout the state of Indiana.

Indianapolis - Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life - the city possesses a variety of professional sports, arts venues, and outdoor recreation areas. Residents of this dynamic city, and surrounding suburbs, enjoy leading educational systems and top-ranked universities, paired with a diverse population. Indianapolis International Airport is a top-ranked international airport, being named "Best Airport in North America" by Airports Council International for many years.

Successful candidates should have a Ph.D. degree or equivalent from an accredited institution and possess excellent understanding of basic neurobiology of neurodegenerative diseases and mechanisms of neurodegeneration. Specific responsibilities include keen knowledge of experimental design, underlying scientific principles, the ability to analyze and assess results, and data preparation for papers and grants. The candidate must have excellent spoken and written skills in the English language.

To apply, please send a letter of application, a summary of research experience, curriculum vitae and the contact information for 3 individuals willing to serve as a reference for you. All materials should be attached to an email sent to:

Bradley S. Glazier

Research Coordinator

Dementia Laboratory

Department of Pathology & Laboratory Medicine

Indiana University School of Medicine

E-mail: bsglazie@iu.edu